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Piperacillin sodium

产品编号 T1213Cas号 59703-84-3
别名 哌拉西林钠, Sodium piperacillin, Piperacillin sodium salt, CL227193

Piperacillin sodium salt(CL227193) )是一种β-内酰胺类广谱抗生素。

Piperacillin sodium

Piperacillin sodium

纯度: 99.66%
产品编号 T1213 别名 哌拉西林钠, Sodium piperacillin, Piperacillin sodium salt, CL227193Cas号 59703-84-3

Piperacillin sodium salt(CL227193) )是一种β-内酰胺类广谱抗生素。

规格价格库存数量
25 mg¥ 245现货
50 mg¥ 355现货
100 mg¥ 498现货
200 mg¥ 742现货
1 mL x 10 mM (in DMSO)¥ 553现货
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"Piperacillin sodium"的相关化合物库

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纯度:99.66%
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产品介绍

生物活性
产品描述
(CL227193) )binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. Piperacillin Sodium is the sodium salt of piperacillin, a broad-spectrum semisynthetic, ampicillin-derived ureidopenicillin antibiotic with bactericidal activity. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.
体内活性
Piperacillin对阳性/阴性革兰氏和需氧/厌氧细菌具有体外抗菌活性。Piperacillin通过与青霉素结合蛋白结合进行调节抑制细菌细胞壁合成。各种β-内酰胺酶,包括头孢菌素酶、青霉素酶以及广谱β-内酰胺酶均无法使Piperacillin水解。
激酶实验
Inhibition of Prostaglandin Formation: Recombinant COX-1 and COX-2 from rat (rCOX) and human (hCOX) expressed in a baculovirus system are purified and reconstituted with 2 mM phenol and 1 μM hematin. Then the cyclooxygenase activity is measured using a radiometric assay, and the specific activity of the final enzyme preparations used is between 20,000 and 35,000 units. Ketorolac (2 -15 μL) are diluted in DMSO and preincubated with the appropriate recombinant COX (3 -15 ng) at a final concentration of 0.01 to 1000 μM in a reaction mixture (150 μL) containing 50 mM Tris-HCl buffer (pH 7.9), 2 mM EDTA, 10% glycerol, 2 mM phenol, and 1 μM hematin for 10 minutes. The reaction is initiated by addition of [14C]arachidonic acid (50–60 mCi/mmol in a final concentration of 20 μM) and is terminated 45 seconds later by the addition of 100 μL of 0.2 N HCl and 750 μL of distilled water. The total reaction volume is then applied to a 1 mL C18 Sep-pak column that has previously been washed with 2 mL of methanol followed by 5 mL of deionized water. Oxygenated products are eluted with 3 mL of a mixture of acetonitrile/water/acetic acid (50:50:0.1, v/v/v) and quantified by liquid scintillation spectroscopy.
别名哌拉西林钠, Sodium piperacillin, Piperacillin sodium salt, CL227193
化学信息
分子量539.54
分子式C23H26N5NaO7S
CAS No.59703-84-3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
H2O: 92 mg/mL (170.5 mM)
Ethanol: 93 mg/mL (172.4 mM)
DMSO: 93 mg/mL (172.4 mM)
溶液配制表
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.8534 mL9.2672 mL18.5343 mL92.6715 mL
5 mM0.3707 mL1.8534 mL3.7069 mL18.5343 mL
10 mM0.1853 mL0.9267 mL1.8534 mL9.2672 mL
20 mM0.0927 mL0.4634 mL0.9267 mL4.6336 mL
50 mM0.0371 mL0.1853 mL0.3707 mL1.8534 mL
100 mM0.0185 mL0.0927 mL0.1853 mL0.9267 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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关键词

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